List of Publications



1.      M.E. Goldberg

         Sur le mécanisme d'action et l'interaction entre les sous-unités de la tryptophane synthétase d'Escherichia coli K12.

         Thèse de Doctorat d'Etat, soutenue le 7 janvier 1967 ˆ la Faculté des Sciences, Paris


2.      M.E. Goldberg, T.E. Creighton, R.L. Baldwin & C. Yanofsky (1966)

Subunit structure of the tryptophane synthetase of Escherichia coli.

J  Mol. Biol. 21:71-82


3.      M.E. Goldberg & R.L. Baldwin (1967)

         Interactions between the subunits of the tryptophan synthetase of Escherichia coli. Optical properties of an intermediate bound to the a2b2 complex.

         Biochemistry 6:2113-2119


4.      A. Ullmann, M.E. Goldberg, D. Perrin & J. Monod (1968)

         On the determination of the molecular weight of proteins and protein subunits in the presence of 6M guanidine hydrochloride.

         Biochemistry 7:261-265


5.      M.E. Goldberg, S. York & L. Stryer (1968)

         Fluorescence studies of substrate and subunit interactions in the b2 protein of Escherichia coli tryptophan synthetase.

         Biochemistry 7:3662-3667


6.      W. Leuzinger, M.E. Goldberg & E. Cauvin (1969)

         Molecular properties of acetylcholinesterase.

         J. Mol. Biol. 40:217-225


7.      M.E. Goldberg & S.J. Edelstein (1969)

         Sedimentation equilibrium of paucidisperse systems. Subunit structure of complemented b-galactosidase.

         J. Mol. Biol. 46:431-440


8.      M.E. Goldberg (1969)

         Tertiary structure of Escherichia coli b-D-galactosidase.

         J. Mol. Biol. 46:441-446


9.      M.E. Goldberg (1970)

         Structural studies of w-complemented b-galactosidase of Escherichia coli.

         In: "The lactose Operon", pp. 273-278. J. Beckwith & D. Zipser, eds. Cold Spring Harbor Laboratory, Cold Spring Harbor


10.    M.H. Buc, A. Ullmann, M.E. Goldberg & H. Buc (1971)

         Masse moléculaire et coefficient d'extinction de la glycogène phosphorylase b du muscle de lapin.

         Biochimie 53:283-289


11.    J. London & M.E. Goldberg (1972)

         The tryptophanase from Escherichia coli K12. I. Purification, physical properties and quaternary structure.

         J. Biol. Chem. 247:1556-1570


12.    J. London & M.E. Goldberg (1973)

         Purification de la tryptophanase d'Escherichia coli par la centrifugation zonale.

         In: "European Symposium of Zonal Centrifugation in Density Gradient", pp. 121-125. ed. Cité Nouvelle, Paris


13.    O. Raibaud & M.E. Goldberg (1973)

         The tryptophanase from Escherichia coli K12. II. Comparison of the thermal stabilities of apo-, holo- and hybrid enzymes.

         J. Biol. Chem. 248:3451-3455


14.    M. Camier, P. Gonnard & M.E. Goldberg (1973)

         Mechanism of coenzyme activity of pyridoxal-5'-phosphate hydrazones.

         Biochimie 55:1011-1019


15.    O. Raibaud & M.E. Goldberg (1973)

         Characterization of two complementary polypeptide chains obtained by proteolysis of rabbit muscle phosphorylase.

         Biochemistry 12:5154-5161


16.    M.E. Goldberg (1973)

         L'état natif est-il l'état fondamental ?

         In: "Dynamic Aspects of Conformation Changes in Biological Macromolecules", pp. 57-65. C. Sadron, ed


17.    C. Skrzynia, J. London & M.E. Goldberg (1974)

         The tryptophanase from Escherichia coli K12. III. Further characterization of hybrids between the apo- and holoenzyme.

         J. Biol. Chem. 249:2325-2326


18.    O. Raibaud & M.E. Goldberg (1974)

         A revised method for the tritium labeling of pyridoxal-5'-phosphate.

         FEBS Letters 40:41-44


19.    J. London, C. Skrzynia & M.E. Goldberg (1974)

         Renaturation Escherichia coli tryptophanase after exposure to 8M urea: evidence for the existence of nucleation centers.

         Eur. J. Biochem. 47:409-415


20.    A. Hšgberg-Raibaud, O. Raibaud & M.E. Goldberg (1975)

         Kinetic and equilibrium studies of the activation of Escherichia coli K12 tryptophanase by pyridoxal-5'-phosphate and monovalent cations.

         J. Biol. Chem. 250:3352-3358


21.    C. Vimard, G. Orsini & M.E. Goldberg (1975)

         Renaturation of acid-denatured rabbit muscle aldolase. Existence and properties of a stable monomeric intermediate.

         Eur. J. Biochem. 51:521-527


22.    O. Raibaud, A. Hšgberg-Raibaud & M.E. Goldberg (1975)

         Purification of Escherichia coli enzymes by chromatography on amphiphilic gels.

         FEBS Letters 50:130-134


23.    M.E. Goldberg, G. Orsini, A. Hšgberg-Raibaud & O. Raibaud (1975)

         Relation between the quaternary structure and the function of oligomeric enzymes.

         FEBS Proceedings (Paris) ASP. Biological and Medical Press B.V. 40:25-34


24.    G. Orsini, C. Skrzynia & M.E. Goldberg (1975)

         The renaturation of reduced polyalanyl-chymotrypsinogen and chymotrypsinogen.

         Eur. J. Biochem. 59:433-440


25.    O. Raibaud & M.E. Goldberg (1976)

         Structural and functional interdependence of the protomers of Escherichia coli K12 tryptophanase during the binding of pyridoxal-5'-phosphate.

         J. Biol. Chem. 251:2814-2819


26.    O. Raibaud & M.E. Goldberg (1976)

         The dissociated tryptophanase subunit is inactive.

         J. Biol. Chem. 251:2820-2824


27.    A. Hšgberg-Raibaud & M.E. Goldberg (1977)

         Preparation and characterization of a modified form of the b2 subunit of Escherichia coli tryptophan synthetase suitable for investigating protein folding.

         Proc. Natl. Acad. Sci. USA 74:442-446


28.    O. Raibaud & M.E. Goldberg (1977)

         The reactivity of one essential cysteine as a conformational probe in Escherichia coli tryptophanase. Application to the study of the structural influence of subunit interactions.

         Eur. J. Biochem. 73:591-599


29.    A. Hšgberg-Raibaud & M.E. Goldberg (1977)

         Isolation and characterization of independently folding regions of the b-chain of Escherichia coli tryptophan synthetase.

         Biochemistry 16:4014-4020


30.    M. Decastel & M.E. Goldberg (1978)

         The substrate binding site specificity of a modified tryptophan synthetase b2 subunit from Escherichia coli.

         FEBS Letters 89:64-68


31.    G. Orsini & M.E. Goldberg (1978)

         The renaturation of reduced chymotrypsinogen A in guanidine-HCl; refolding versus aggregation.

         J. Biol. Chem. 253:3453-3458


32.    I.P. Crawford, M. Decastel & M.E. Goldberg (1978)

         Assignment of the ends of the b-chain of Escherichia coli tryptophan synthetase to the F1 and F2 domains.

         Biochem. Biophys. Res. Commun. 85:309-316


33.    M.E. Goldberg (1979)

         Limited proteolysis as a probe of the polyglobular organization of proteins.

         In: "Limited Proteolysis in Microorganisms", pp. 187-189. G.N. Cohen & H. Holzer, eds. DHEW Publication N¡ (NIH) 79-1591. Washington, D.C.: US. Government Printing Office


34.    M.E. Goldberg & A. Hšgberg-Raibaud (1979)

         Conformational and ligand binding properties of the isolated domains from the b2 subunit of Escherichia coli tryptophan synthetase investigated by the reactivity of their cysteines.

         J. Biol. Chem. 254:7752-7757


35.    M.M. Zakin, G. Boulot & M.E. Goldberg (1980)

         Immunochemical study of the b-chain of Escherichia coli tryptophan synthetase and its proteolytic fragments.

         Eur. J. Immunol. 10:16-21


36.    C.R. Zetina & M.E. Goldberg (1980)

         Reversible unfolding of the b2 subunit of Escherichia coli tryptophan synthetase and its proteolytic fragments.

         J. Mol. Biol. 137:401-414.


37.    M.E. Goldberg & C.R. Zetina (1980)

         Importance of interdomain interactions in the structure function and stability of the F1 and F2 domains isolated from the b2 subunit of E.coli tryptophan synthetase.

         In: "Protein Folding", pp. 469-484. R. Jaenicke, ed. Elsevier/North-Holland. Biomedical Press


38.    C.R. Zetina & M.E. Goldberg (1980)

         A comparative study of the thermal inactivation of the isolated and associated domains within the b2 subunit of Escherichia coli tryptophan synthetase: evidence for strong interdomain interactions.

         J. Biol. Chem. 255:4381-4385


39.    A.F. Chaffotte, M.M. Zakin & M.E. Goldberg (1980)

         Immunochemical studies on the evolution of tryptophanase and the two subunits of tryptophan synthetase of Escherichia coli K12.

         Biochem. Biophys. Res. Commun. 92:381-388


40.    M.E. Goldberg (1980)

         Le tri automatique de cellules par cytofluorographie.

         Ann. Immunol. (Institut Pasteur) 131D:347-355


41.    C.R. Zetina & M.E. Goldberg (1982)

         Kinetics of renaturation and self-assembly of intermediates on the pathway of folding of the b2-subunit of Escherichia coli tryptophan synthase.

         J. Mol. Biol. 157:133-148


42.    P. Métézeau, L. Djavadi-Ohaniance & M.E. Goldberg (1982)

         The kinetics and homogeneity of endocytosis of a receptor-bound ligand in a heterogeneous cell population studied by Flow Cytofluorometry.

         J. Histochem. Cytochem. 30:359-363


43.    A. Bernheim, P. Métézeau, G. Guella‘n, J. Weissenbach, M. Fellous, M.E. Goldberg & R. Berger (1982)

         Une méthode d'identification par hybridation moléculaire de chromosomes purifiés avec un trieur de cellules.

         C. R. Acad. Sci. (Paris) 295:439-442


44.    B. Friguet, L. Djavadi-Ohaniance, J. Pagès, A. Bussard & M.E. Goldberg (1983)

         A convenient enzyme-linked immunosorbent assay for testing whether mono-clonal antibodies recognize the same antigenic site. Application to hybridomas specific for the b2 subunit of Escherichia coli.

         J. Immunol. Methods 60:351-358


45.    A.F. Chaffotte & M.E. Goldberg (1983)

         Immunochemical evidence for conformational flexibility and its modulation by specific ligands in the b2 subunit of E.coli tryptophan synthase.

         Biochemistry 22:2708-2714


46.    M.E. Goldberg & A.F. Chaffotte (1983)

         Comparaison de la tryptophanase et de la tryptophane synthétase d'Escherichia coli.

         Dans: "L'Evolution des Protéines", pp. 85-91. G. Lucotte, ed. (Collection Biologie Evolutive n¡ 8). Masson, Paris


47.    B. Friguet, L. Djavadi-Ohaniance & M.E. Goldberg (1983)

         A convenient enzyme-linked immunosorbent assay for testing whether monoclonal antibodies recognize the same antigenic site.

         In: "Immunoenzymatic Techniques", pp. 171-174. S. Avraméas et al., eds. Elsevier Science Publishers B.V


48.    M.E. Goldberg (1983)

         An immunochemical study of the change in conformation undergone by two domains of the tryptophan synthetase b2 subunit upon association.

         In: "Protein Conformation as an Immunological Signal", pp. 201-210. F. Celada, V.N. Schumaker & E.E. Sercarz, eds. Plenum Publishing Corporation.


49.    A. Bernheim, P. Métézeau, G. Guella‘n, M. Fellous, M.E. Goldberg & R. Berger (1983)

         Direct hybridization of sorted human chromosomes, localization of the Y chromosome on flow karyotype.

         Proc. Natl. Acad. Sci. USA 80:7571-7575


50.    A.F. Chaffotte & M.E. Goldberg (1984)

         Fluorescence-quenching studies on a conformational  transition within a domain of the b2 subunit of E.coli tryptophan synthase.

         Eur. J. Biochem. 139:47-50


51.    L. Djavadi-Ohaniance, B. Friguet & M.E. Goldberg (1984)

         Structural and functional influence of enzyme-antibody interactions: effects of eight different monoclonal antibodies on the enzymatic activity of E.coli tryptophan synthase.

         Biochemistry 23:97-104


52.    B. Baron, P. Métézeau, F. Kelly, A. Bernheim, R. Berger, J.L. Guénet & M.E. Goldberg (1984)

         Flow cytometry isolation and improved visualization of sorted mouse chromosomes: purification of chromosomes X and iso-1 from cell lines with robertsonian translocations.

         Exp. Cell Res. 152:220-230


53.    P. Métézeau, A. Bernheim, R. Berger & M.E. Goldberg (1984)

         A simple device to obtain high local concentrations of material sorted by flow cytometry for biochemical or morphological analysis.

         Cytometry 5:550-552


54.    B. Friguet, L. Djavadi-Ohaniance & M.E. Goldberg (1984)

         Some monoclonal antibodies raised with a native protein bind preferentially to the denatured antigen.

         Mol. Immunol. 21:673-677


55.    P. Métézeau, I. Elguindi & M.E. Goldberg (1984)

         Endocytosis of the membrane immunoglobulins of mouse spleen B-cells: a quantitative study of its rate, amount and sensitivity to physiological, physical and cross-linking agents.

         EMBO J. 3:2235-2242


56.    B. Friguet, A.F. Chaffotte, L. Djavadi-Ohaniance & M.E. Goldberg (1985)

         Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay.

         J. Immunol. Methods 77:305-319


57.    S. Blond & M.E. Goldberg (1985)

         Kinetics and importance of the dimerization step in the folding pathway of the b2 subunit of E.coli tryptophan synthase.

         J. Mol. Biol. 182:597-606


58.    A.F. Chaffotte, L. Djavadi-Ohaniance & M.E. Goldberg (1985)

         Does a monospecific hybridoma always secrete homogeneous immuno- globulins ?

         Biochimie 67:75-82.


59.    I. Elguindi, G. Redziniak, P. Métézeau, A. Meybeck & M.E. Goldberg (1985)

         Modulation of membrane receptor endocytosis by chemical effectors of membrane fluidity.

         Biol. of the Cell 54:199-206


60.    M.E. Goldberg (1985)

         The second translation of the genetic message: protein folding and assembly.

         Trends in Biochem. Sci. 10:388-391

61.    P. Métézeau, B. Baron & M.E. Goldberg (1985)

         Fluorescence and fluorochromes in flow cytometry.

         In: "Transplantation and Clinical Immunology", vol. XVII, pp. 217-222. J.L. Touraine et al., eds. Elsevier Science Publishers B.V


62.    B. Baron, P. Métézeau, D. Hatat, C. Roberts, M.E. Goldberg & C. Bishop (1986)

         Cloning of DNA libraries from mouse Y chromosomes purified by flow cytometry.

         Somatic Cell and Molecular Genetics 12:289-295


63.    L. Djavadi-Ohaniance, B. Friguet & M.E. Goldberg (1986)

         Conformational effects of ligand binding on the b2 subunit of Escherichia coli tryptophan synthase analyzed with monoclonal antibodies.

         Biochemistry 25:2502-2508


64.    A. Achour, U. Hazan, M.T. Nugeyre, F. Barre-Sinoussi, P. Métézeau, H. Gachelin, F. Chapuis, D. Klatzman, J.C. Gluckman, M.E. Goldberg & J.C. Chermann (1986)

         A binding assay to identify HIV (LAV) target cells.

         Ann. Virology (Institut Pasteur) 137E:291-302


65.    S. Blond & M.E. Goldberg (1986)

         Kinetic characterization of early intermediates in the folding of Escherichia coli tryptophan synthase b2 subunit.

         Proteins: Structure, Function and Genetics 1:247-255


66.    B. Friguet, L. Djavadi-Ohaniance & M.E. Goldberg (1986)

         Conformational changes induced by domain assembly within the b2 subunit of Escherichia coli tryptophan synthase analyzed with monoclonal antibodies.

         Eur. J. Biochem. 160:593-597


67.    Y. Milner, B. Michel, E. Sagi, K. Holubar, P. Métézeau & M.E. Goldberg (1987)

         Binding modes, elution and estimation of pemphigus-IgG in pemphigus skin and on guinea pig keratinocytes.

         In: "Cellular, Molecular and Genetic Approach to Immunodiagnosis and Immunotherapy", pp. 413-419. K. Kano, S. Mori, T. Sugiyasaki & M. Torisu, eds. University of Tokyo Press


68.    S. Blond & M.E. Goldberg (1987)

         Partly native epitopes are already present on early intermediates in the folding of tryptophan synthase.

         Proc. Natl. Acad. Sci. USA 84:1147-1151


69.    P. Wilhelm, B. Friguet, L. Djavadi-Ohaniance, I. Pilz & M.E. Goldberg (1987)

         Epitope localization in antigen-monoclonal-antibody complexes by small-angle X-ray scattering. An approach to domain organization in the b2 subunit of Escherichia coli tryptophan synthase.

         Eur. J. Biochem. 164:103-109


70.    A.F. Chaffotte & M.E. Goldberg (1987)

         Kinetics of the spontaneous transient unfolding of a native protein studied with monoclonal antibodies. Monomer/Dimer transition in the tryptophan-synthase b2 subunit.

         J. Mol. Biol. 197:131-140


71.    B. Pichard, P. Rich, M. Spiro, F. Biraben, G. Grynberg, P. Verkerk, M.E. Goldberg & P. Fayet (1987)

         On the possibility of detecting superheavy hydrogen through centrifugation and atomic spectroscopy.

         Physics Letters 193:383-388


72.    M. Goldberg (1987)

         Protein folding, or the second translation of the gene.

         In: "From Enzyme Adaptation to Natural Philosophy: Heritage from Jacques Monod". E. Quagliariello, G. Bernardi & A. Ullmann, eds. Elsevier


73.    M.E. Goldberg (1988)

         L'analyse et le tri de cellules par cytométrie en flux.

         Dans: "La Presse Médicale", Tome 17 (n¡ 25), pp. 1287-1289. Masson, ed., Paris


74.    P. Couillin, P. Métézeau, D. Hatat, R. Bono, M. Goldberg, M. Revel & M. Fellous (1988)

         La génétique moléculaire.

         Dans: "La Cytométrie en Flux", Vol. I, pp. 99-111. P. Métézeau, X. Ronot, G. Le Noan, M.H. Ratinaud, eds. Medsi/McGraw-Hill, Paris


75.    B. Baron, P. Métézeau, P. Avner, C. Bishop & M.E. Goldberg (1988)

         Tri et clonage de chromosomes de souris. Application à la constitution de banques génomiques.

         Dans: "La Cytométrie en Flux", Vol. I, pp. 271-276. P. Métézeau, X. Ronot, G. Le Noan, M.H. Ratinaud, eds. Medsi/McGraw-Hill, Paris


76.    M. Goldberg (1988)

         Difficultés et limites.

         Dans: "La Cytométrie en Flux", Vol. I, pp. 357-367. P. Métézeau, X. Ronot, G. Le Noan, M.H. Ratinaud, eds. Medsi/McGraw-Hill, Paris


77.    A. Murry-Brelier & M.E. Goldberg (1988)

         Kinetics of appearance of an early immunoreactive species during the refolding of acid-denatured Escherichia coli tryptophan synthase b2 subunit.

         Biochemistry 27:7633-7640


78.    S. Blond-Elguindi, B. Friguet & M.E. Goldberg (1988)

         Renaturation of guanidine-unfolded tryptophan synthase by multimixing stopped-flow dilution in D2O.

         FEBS Letters 241:251-256


79.    M. Goldberg (1988)

         Une polytechnique bio-physico-chimique: l'analyse et le tri automatisé de populations cellulaires.

         Dans: "La Jaune et la Rouge", numéro spécial "La Biologie", n¡ 436, pp. 65-69. Revue mensuelle de la S Amicale des Anciens Elèves de l'Ecole Polytechnique, juin-juillet 1988


80.    B. Friguet, L. Djavadi-Ohaniance & M.E. Goldberg (1989)

         Immunochemical analysis of protein conformation.

         In: "Protein Structure: a practical approach", Chapter 12, pp. 287-310. T. Creighton, ed. IRL Press Oxford-New York-Tokyo


81.    A. Murry-Brelier & M.E. Goldberg (1989)

         A physical-chemical and immunological comparison shows that native and renatured Escherichia coli tryptophan synthase b2 subunits are identical.

         Biochimie 71:533-543


82.    A. Murry-Brelier & M.E. Goldberg (1989)

         Alternate succession of steps can lead to the folding of a multidomain oligomeric protein.

         Proteins: Structure, Function, and Genetics 6:395-404


83.    B. Friguet, L. Djavadi-Ohaniance & M.E. Goldberg (1989)

         Polypeptide-antibody binding mechanism: conformational adaptation investigated by equilibrium and kinetic analysis.

         Res. Immunol. 140:355-376

84.    Y. Milner, E. Sagi, R. Timberg, B. Michel, P. Métézeau & M.E. Goldberg (1989)

         Binding modes of IgG from Pemphigus autoimmune sera onto guinea pig keratinocytes and the fate of bound IgGs.

         J. Cell. Physiol. 139:441-454


85.    T.M. Callaghan, P. Métézeau, H. Gachelin, G. Redziniak, Y. Milner & M.E. Goldberg (1990)

         Modulation of the binding and endocytosis of concanavalin A by guinea pig keratinocytes: reversible antagonistic effects of cholesterol and phospholipid-liposomes.

         J. Invest. Dermatol. 94:58-64


86.    A. Murry-Brelier & M.E. Goldberg (1990)

         Mechanism of inactivation of the b2 subunit of Escherichia coli tryptophan synthase by monoclonal antibodies.

         J. Biol. Chem. 265:7987-7993


87.    S. Blond-Elguindi & M.E. Goldberg (1990)

         Kinetic characterization of early immunoreactive intermediates during the refolding of guanidine-unfolded Escherichia coli tryptophan synthase b2 subunits.

         Biochemistry 29:2409-2417


88.    M.E. Goldberg, G.V. Semisotnov, B. Friguet, K. Kuwajima, O.B. Ptitsyn & S. Sugai (1990)

         An early immunoreactive folding intermediate of the tryptophan synthase b2 subunit is a "Molten Globule".

         FEBS Letters 263:51-56


89.    B. Friguet, L. Djavadi-Ohaniance, C.A. Haase-Pettingel, J. King & M.E. Goldberg (1990)

         Properties of monoclonal antibodies selected for probing the conformation of wild type and mutant forms of the P22 tailspike endorhamnosidase.

         J. Biol. Chem. 265:10347-10351


90.    M.E. Goldberg (1990)

         Folding of a multidomain oligomeric protein. The b2 subunit of Escherichia coli tryptophan synthase.

         In: "Protein Folding: Deciphering the Second Half of the Genetic Code", pp. 141-154. L. Gierasch and J. King, eds. AAAS-Washington D.C


91.    B. Baron, P. Métézeau, H. Kiefer-Gachelin & M.E. Goldberg (1990)

         Construction and characterization of a DNA library from mouse chromosome 19 purified by flow cytometry.

         Biology of the Cell 69:1-8


92.    S. Blond-Elguindi & M.E. Goldberg (1990)

         Conformational change of the N-terminal domain of the Escherichia coli tryptophan synthase b2 subunit induced by its interactions with monoclonal antibodies.

         Res. Immunol. 141:879-892


93.    B. Pichard, J. Rich, J.P. Soirat, M. Spiro, S. Zylberajch, G. Grynberg, F. Trehin, P. Verkerk, M.E. Goldberg & P. Fayet (1990)

         Search for superheavy hydrogen in sea water.

         In: "New and Exotic Phenomena '90": Proceedings of the XXVth Rencontre de Moriond, Les Arcs, pp. 489-498. O. Fackler and J. Tran Thanh V‰n, eds. Editions Frontières


94.    M.-P. Larvor, L. Djavadi-Ohaniance, B. Friguet, F. Baleux & M.E. Goldberg (1991)

         Peptide/Antibody recognition: synthetic peptides derived from the E. coli tryptophan synthase b2 subunit interact with high affinity with an anti-b2 monoclonal antibody.

         Molec. Immunol. 28:523-531

95.    M.E. Goldberg, R. Rudolph & R. Jaenicke (1991)

         A kinetic study of the competition between renaturation and aggregation during the refolding of denatured-reduced egg white lysosyme.

         Biochemistry 30:2790-2797


96.    M. Delepierre, M.-P. Larvor, F. Baleux & M.E. Goldberg (1991)

         1H NMR conformational analysis of a high affinity antigenic 11-residue peptide from the tryptophan synthase b2 subunit.

         Eur. J. Biochem. 201:681-693


97.    A. Chaffotte, Y. Guillou, M. Delepierre, H.J. Hinz & M.E. Goldberg (1991)

         The isolated C-terminal (F2) fragment of the E. coli tryptophan synthase b2 subunit folds into a stable, organized non-native conformation.

         Biochemistry 30:8067-8074


98.    P. Métézeau, C. Cotinot, G. Colas, M. Azoulay, H. Kiefer, M.E. Goldberg & M. Kirszenbaum (1991)

         Improvement of flow cytometry analysis and sorting of bull spermatozoa by optical monitoring of cell orientation as evaluated by DNA specific probing.

         Molecular Reproduction and Development 30:250-257


99.    M.E. Goldberg (1991)

         Investigating protein conformation, dynamics and folding with monoclonal antibodies.

         Trends in Biochem. Sci. 16:358-362


100.  A. Chaffotte, C. Cadieux, Y. Guillou & M.E. Goldberg (1992)

         A possible precursor to the "molten globule": the C-terminal proteolytic domain of tryptophan synthase b chains folds in less than 4 milliseconds into a hydrophobic condensed state with non native-like secondary structure.

         Biochemistry. 31:4303-4308


101.  A.F. Chaffotte, Y. Guillou & M.E. Goldberg (1992)

         Inclusion bodies of the thermophilic endoglucanase D from Clostridium thermocellum are made of native enzyme that resists 8 M urea.

         Eur. J. Biochem. 205:369-373


102.  P. Verkerk, G. Grynberg, B. Pichard, M. Spiro, S. Zylberajch, M.E. Goldberg & P. Fayet (1992)

         Search for superheavy hydrogen in sea water.

         Physical Review Letters 68:1116-1119


103.  G.A. Elšve, A.F. Chaffotte, H. Roder & M.E. Goldberg (1992)

         Early steps in cytochrome c folding probed by time-resolved circular dichroism and fluorescence spectroscopy.

         Biochemistry 31:6876-6883


104.  A.F. Chaffotte, Y. Guillou & M.E. Goldberg (1992)

         Kinetic resolution of peptide bond and side chain far-UV circular dichroism during the folding of hen egg white lysozyme.

         Biochemistry 31:9694-9702


105.  A.N. Fedorov, B. Friguet, L. Djavadi-Ohaniance, Y.B. Alakhov & M.E. Goldberg (1992)

         Folding on the ribosome of Escherichia coli tryptophan synthase b subunit nascent chains probed with a conformation-dependent monoclonal antibody.

         J. Mol. Biol. 228:351-358


106.  B. Friguet, A. Fedorov, A.A. Serganov, A. Navon & M.E. Goldberg (1993)

         A Radio-Immuno-Assay based method for measuring the true affinity of a monoclonal antibody with trace amounts of radioactive antigen. Illustration with the products of a cell free protein synthesis system.

         Analytical Biochemistry 210:344-350

107.  M.E. Goldberg & L. Djavadi-Ohaniance (1993)

         Methods for measurement of antibody/antigen affinity based on ELISA and RIA.

         Current Opinion in Immunology 5:278-281


108.  H.-J. Linkens, L. Djavadi-Ohaniance & M.E. Goldberg (1993)

         Nicking of the tryptophan synthase b2-dimer at Glu-296 prevents the conformational change undergone on binding specific ligands.

         FEBS Letters 320:224-228


109.  M.M. Ziegler, M.E. Goldberg, A.F. Chaffotte & T.O. Baldwin (1993)

         Refolding of Luciferase subunits from urea and assembly of the active heterodimer. Evidence for folding intermediates that precede and follow the dimerization step on the pathway to the active form of the enzyme.

         J. Biol. Chem. 268:10760-10765


110.  T.O. Baldwin, M.M. Ziegler, A.F. Chaffotte & M.E. Goldberg (1993)

         Contribution of folding steps involving the individual subunits of bacterial Luciferase to the assembly of the active heterodimeric enzyme.

         J. Biol. Chem. 268:10766-10772


111.  M.-P. Larvor, L. Djavadi-Ohaniance, B. Nall & M.E. Goldberg (1994)

         Measurement of the dissociation rate constant of antigen/antibody complexes in solution by enzyme-linked immunosorbent assay.

         J. Immunol. Methods 170:167-175


112.  M.E. Goldberg & Y. Guillou (1994)

         Native disulfide bonds greatly accelerate secondary structure formation in the folding of lysozyme.

         Protein Science 3:883-887


113.  B. Friguet, L. Djavadi-Ohaniance, J. King & M.E. Goldberg (1994)

         In vitro and ribosome-bound folding intermediates of P22 tailspike protein detected with monoclonal antibodies.

         J. Biol. Chem. 269:15945-15949


114.  A. Pintar, A. Chollet, C. Bradshaw, A. Chaffotte, C. Cadieux, M.J. Rooman, K. Hallenga, J. Knowles, M. Goldberg & S.J. Wodak (1994)

         Conformational properties of four peptides corresponding to a-helical regions of Rhodospirillum cytochrome c2 and bovine calcium binding protein.

         Biochemistry 33:11158-11173


115.  M.E. Goldberg & A.F. Chaffotte (1994)

         Circular dichroism stopped-flow studies of folding intermediates.

         In: "Statistical Mechanics, Protein Structure, and Protein Substrate Interactions", pp. 19-29, S. Doniach ed., Plenum Press, New York, 1994


116.  J.I. Guijarro, M. Jackson, A.F. Chaffotte, M. Delepierre, H.H. Mantsch & M.E. Goldberg (1995)

         Protein folding intermediates with rapidly exchangeable amide protons contain authentic hydrogen bonded secondary structures.

         Biochemistry 34:2998-3008


117.  A. Navon, A.J. Schulze, Y. Guillou, C.A. Zylinski, F. Baleux, N. Expert-Bezançon, B. Friguet, L. Djavadi-Ohaniance & M.E. Goldberg (1995)

         Importance of residues 2-9 in the immunoreactivity, subunit interactions and activity of the b2 subunit of Escherichia coli tryptophan synthase.

         J. Biol. Chem. 270:4255-4261


118.  K. Tokatlidis, B. Friguet, D. Deville-Bonne, F. Baleux, A.N. Fedorov, A. Navon, L. Djavadi-Ohaniance & M.E. Goldberg (1995)

         Nascent chains: folding and chaperone interaction during elongation on ribosomes.

         Philosophical Transactions of the Royal Society of London 348:89-95


119.  B. Friguet, A.F. Chaffotte, L. Djavadi-Ohaniance & M.E. Goldberg (1995)

Under proper experimental conditions the solid-phase antigen does not disrupt the liquid phase equilibrium when measuring dissociation constants by competition ELISA.

         J. Immunol. Methods 182:145-147


120.  M.E. Goldberg, N. Expert-Bezançon, L. Vuillard & T. Rabilloud (1996)

         Non-detergent Sulphobetaines: a new class of molecules that facilitate in vitro protein renaturation.

         Folding & Design 1:21-27


121.  L. Djavadi-Ohaniance, M.E. Goldberg & B. Friguet (1996)

         Measuring antibody affinity in solution.

         In : Antibody Engineering: a practical approach. J. McCafferty (ed.) Chapitre 4, pp. 77-97, IRL Press, Oxford, New York, Tokyo


122.  T. Planchenault, A. Navon, A.J. Schulze & M.E. Goldberg (1996)

         Transient non-native interactions in early folding intermediates do not influence the folding kinetics of Escherichia coli tryptophan-synthase b2 subunits.

         Eur. J. Biochem. 240:615-621


123.  M. Goldberg (1996)

         Selective interactions and protein polymorphism: from allosteric proteins to the prion (Commemorative lecture).

         Bull. Inst. Pasteur  94:157-171


124.  F. Hardy, L. Djavadi-Ohaniance & M.E. Goldberg (1997)

         Measurement of antibody/antigen association rate constants in solution by a method based on the enzyme-linked immunosorbent assay.

         J. Immunol. Meth. 200:155-159


125.  B. Friguet, L. Djavadi-Ohaniance & M.E. Goldberg (1997)

         Immunochemical analysis of protein conformation.

         in : Protein Structure: a practical approach. (2nd edition) Chapter 13, pp. 323-348. T.E. Creighton (ed.) IRL Press at Oxford University


126.  A.F. Chaffotte, I. Guijarro, Y. Guillou, M. Delepierre & M.E. Goldberg (1997)

         The "pre-molten globule", a new intermediate in protein folding.

         J. Prot. Chemistry 16: 433-439


127   N. Izadi, Y. Henry, J. Haladjian, M.E. Goldberg, C. Wandersman, M. Delepierre & A. Lecroisey (1997)

         Purification and characterization of an extracellular heme-binding protein, HasA, involved in heme iron acqisition.

         Biochemistry 36: 7050-7057


128.  P. Rondard, M.E. Goldberg & H. Bedouelle (1997)

         Mutational analysis of an antigenic peptide shows recognition in a loop conformation.

         Biochemistry 36:8962-8968


129.  P. Roux, M. Delepierre, M.E. Goldberg & A.F. Chaffotte (1997)

         Kinetics of secondary structure regain during the refolding of reduced hen egg white lysozyme.

         J. Biol. Chem. 272:24843-24849


130.  K. Gast, A.-F. Chaffotte, D. Zirwer, Y. Guillou, M. Mueller-Frohne, C. Cadieux, M. Hodges, G. Damaschun & M.E. Goldberg (1997)

         Lack of coupling between secondary structure formation and collapse in a model polypeptide that mimics early folding intermediates, the F2 fragment of the Escherichia coli tryptophan-synthase b chain.

         Protein Science 6:2578-2588


131.  A.-F. Chaffotte, J.-H. Li, R.E. Georgescu, M.E. Goldberg & M.L. Tasayco (1997)

         Recognition between disordered states: kinetics of the self-assembly of thioredoxin fragments.

         Biochemistry 36:16040-16048


132.  J.I. Guijarro, L. Djavadi-Ohaniance, F. Baleux, M. Delepierre & M.E. Goldberg (1998)

         Does a peptide bound to a monoclonal antibody always adopt a unique conformation?

         Res. Immunol. 149:127-137


133.  B. Friguet, L. Djavadi-Ohaniance & M.E. Goldberg (1998)


         in : Encyclopedia of Immunology, 2nd edition, pp. 43-47


134.  M.E. Goldberg (1998)

         Mesure des constantes cinétiques et d'équilibre entre macromolécules en solution par la méthode ELISA.

         Regard sur la Biochimie n¡ 2:16-20


135.  R.E. Georgescu, J.-H. Li, M.E. Goldberg, M.L. Tasayco & A.-F. Chaffotte (1998)

         Proline isomerization-independent accumulation of an early intermediate and heterogeneity of the folding pathways of a mixed a/b protein, Escherichia coli thioredoxin.

         Biochemistry 37:10286-10297


136.  L. Vuillard, T. Rabilloud & M.E. Goldberg (1998)

         Interactions of non-detergent sulfobetaines with early folding intermediates facilitate in vitro protein renaturation.

         Eur. J. Biochem. 256:128-135


137.  M. Delepierre, P. Roux, A.-F. Chaffotte & M.E. Goldberg (1998)

         1H NMR characterization of renatured lysozyme obtained from fully reduced lysozyme under folding/oxidation conditions, a high-resolution liquid NMR study at magic angle spinning.

         Magn. Reson. Chem. 36:645-650


138.  M.E. Goldberg, F. Schaeffer, Y. Guillou & L. Djavadi-Ohaniance (1999)

         Pseudo-native motifs in the noncovalent heme-apocytochrome c complex: evidence from antibody binding studies by ELISA and microcalorimetry.

         J. Biol. Chem. 274: 16052-16061


139.  S. Létoffé, F. Nato, M.E. Goldberg & C. Wandersman (1999)

         Interactions of HasA, a bacterial haemophore, with haemoglobin and with its outer membrane receptor HasR.

         Mol. Microbiol. 33:546-555


140.  R.G. Maroun, D. Krebs, S. El Antri, A. Deroussent, E. Lescot, F. Troalen, H. Porumb, M.E. Goldberg & S. Fermandjian (1999)

         Self-association and Domains of Interaction of an amphipathic helix peptide inhibitor of HIV-1 integrase assessed by analytical centrifugation and NMR experiments in trifluoroethanol/H20 mixtures.

         J. Biol. Chem. 274: 34174-34185


141.  P. Roux, M. Ruoppolo, A.-F. Chaffotte & M.E. Goldberg (1999)

         Comparison of the kinetics of S-S bonf, secondary structure and active site formation during refolding of reduced denatured hen egg white lysozyme.

         Protein Science 8:  2751-2760


142.  R. Eckenberg, T. Rose, J.-L. Moreau, R. Weil, F. Gesbert, S. Dubois, D. Tello, M. Bossus, H. Gras, A. Tartar, J. Bertoglio, S. Choua•b, M. Goldberg, Y. Jacques, P. M. Alzari & J. Theze (2000)

         The first a-helix of IL-2 folds as an homotetramer, acts as an agonist of the IL-2 receptor b chain and induces lymphokine-activated killer cells.

         J. Exp. Medecine 191: 529-540.


143.  J. Dam, T. Rose, M.E. Goldberg & A. Blondel (2000)

         Complementation between dimeric mutants as a probe of dimer-dimer interactions in tetrameric dihydrofolate reductase encoded by R67 plasmid of E. coli.

         J. Mol. Biol. 302:235-250.


144. V. Guez, P. Roux, A. Navon & M.E. Goldberg (2001)

         Role of the C30-C115 disulfide bond in hen lysozyme folding.

         Nova Acta Leopoldina Supplementum 16: 69-70.


145. M.E. Goldberg  (2001)

         In vitro studies on the competition between renaturation and aggregation during protein folding and at equilibrium

         In ÒConformational Diseases: A compendium - Based on the First International Workshop on Conformational Diseases - Beka Solomon, Albert Taraboulos & Ephraim Katchalski-Katzir, Eds - The Center for the Study of Emerging Diseases, Jerusalem Ð pp 54-62.


146. A. Méjean, C. Bodenreider, K. Schuerer & M.E. Goldberg  (2001)

Kinetic characterization of the pH dependent oligomerization of R67 Dihydrofolate Reductase.

Biochemistry  40: 8169-8179.


147. V. Guez, P. Roux, A. Navon & M.E. Goldberg  (2002)

Role of individual disulfide bonds in hen lysozyme early folding steps.

Protein Science  11: 1136-1151.


148.  N.M. Jarrett, L. Djavadi-Ohaniance, R.C. Willson, H. Tachibana & M.E. Goldberg (2002)

         Immunochemical Pulsed-labeling Characterization of Intermediates during Hen Lysozyme Oxidative Folding.

         Protein Science  11:  2584-2595.


149.   C. Bodenreider,  N. Kellershohn, M.E. Goldberg & A. Méjean (2002)

         Kinetic analysis of R67 dihydrofolate reductase folding: from the unfolded monomer to the native tetramer.

  Biochemistry  41: 14988-14999.


150.  N. Expert-Bezançon, T. Rabilloud, L. Vuillard & M.E. Goldberg (2003)

Physical-chemical features of non-detergent sulfobetaines active as folding helpers

Biophysical Chem.   100: 469 - 479


151. A.-G. Planson, J. I. Guijarro, M.E. Goldberg and A.F. Chaffotte (2003)

Assistance of Maltose Binding Protein to the in vivo Folding of the Disulfide-Rich C-Terminal Fragment from Plasmodium falciparum Merozoite Surface Protein 1 Expressed in E. coli 

Biochemistry  42: 13202 - 13211.

152.    M. E. Goldberg (2005)

Le repliement des Protéines : seconde traduction du message génétique.

Médecine Science 21: 563-566.


153.    M. E. Goldberg and A.F. Chaffotte (2005)

Undistorted structural analysis of soluble proteins by attenuated total reflectance infrared spectroscopy.

Protein Science  14:  2781-2792.


154.  P. B. Falanga *, M.-C. Blom-Potar, P. Bittoun, M. E. Goldberg, M.  Hontebeyrie (2006)

Selection of ovine PrP high-producer subclones from a transfected epithelial cell line

             Biochem. Biophys. Res. Com. 340: 309-317.


155.  M. E. Goldberg (2008)

Jacques Monod, Protein Folding and Me. In : Comprehensive Biochemistry, Vol 46, Stories of Success - Personal Recollections, XI, Vladimir P. Skulachev and Giorgio Semenza. The Nederlands: Elsevier, pp 115-230.

156.  G. L. C. Nunes, A. Simoes, F. H. Dyszy, C. S. Shida, M. A. Juliano, L. Juliano, T. F. Gesteira, H. B. Nader, G. Murphy, A. F. Chaffotte, M. E. Goldberg, I. L. S. Tersariol, P. C. Almeida (2011)
             Mechanism of Heparin Acceleration of Tissue Inhibitor of Metalloproteases-1 (TIMP-1) Degradation by the Human Neutrophil Elastase
             PLoS ONE 6: e2155  1-11.